The laboratory debuted in the first episode, Pokémon - I Choose You!, when Ash received his Pikachu. Since then, it has been seen in many episodes, mostly in the start and ending of a region adventure, but also in Pokémon Chronicles and in the movies. The building stands out in Pallet Town for its wind turbine, the three windows of the inner balcony, and for the four windows of the second floor. Every time Ash captures a [[Pokémon] when he has six already with him, the new Pokémon is automatically transported here. Ash also has a habit of leaving all of his Pokémon besides Pikachu here each time he leaves for a new region, starting with Hoenn.
The lab is composed of two floors. Inside the entrance door is a hallway with several doors, and to the left is a chest of drawers and the stairway to the second floor.
The living room is the space where Professor Oak hosts, eats, relaxes, and presumably studies. On a pink carpet (sometimes shown as green) are two couches and a table. To the side are a computer and bookshelves. This is where many scenes in the lab take place. There are also two science rooms full of various machines.
The Poké Ball Storage Room stores the extra Pokémon of every Trainer born in Pallet Town. This treasure of hundreds of Pokémon has been the target of attempted robberies by Team Rocket. In addition, the lab has a library, composed of two rooms. One is a study room with a large bookshelf and a pair of windows. The other, in the back, is a storage room full of books, including Oak's old sketchbook.
Upstairs is the research floor. Here are all the technological pieces, the heart of the laboratory. It includes several machines used for Pokémon testing and a table with various chemicals on it. Nearby is a blue chair. In front of it are the status screen, which shows the health and power of a Pokémon, and Professor Oak's computer, where he records his research. This computer doubles as a videophone, which he uses to communicate with other professors or Trainers. Beside the computer is the Poké Ball Transfer machine, for the transportation of Pokémon to their Trainers in a Pokémon Center. The room also includes a bookshelf, a desk with a lamp, a brown couch, and a drawing board. A few machines are connected to a glass container full of water, possibly to study aquatic Pokémon. Hanging from the ceiling is a large lamp.
The stairs lead up to an inner balcony, which has a door and the three large windows seen in most outside views of the lab.
The Oak Corral is a natural environment for Pokémon development. It is divided into regions according to type; there are areas that are perfect for Rock Pokémon, desert areas for Ground and Fire-types, grassy regions for Grass-type Pokémon, and several lakes for Water-type Pokémon. Sometimes the Pokémon don't get along; for this reason, some Pokémon, such as Ash's Bulbasaur, act as mediators between quarreling Pokémon.