A Pokémon Center is a center located all around the Pokémon World. They are run by a Nurse Joy that runs on helping Pokémon recover their energy when hurt. It takes a while, but has a wide area for Trainers to rest in and sleep in, and also a receiving system to retrieve new Poké Balls.

Pokémon Centers are designed for Trainers so they can rest between activities. Trainers use Pokémon Centers as gathering places, so they can share information about Pokémon. They also have access to video phones, PCs with trading functions and most offer free food and lodging. As a Pokémon journey can take a long time, Pokémon Centers can be used as mailing destinations. A Trainer can arrange for their loved ones to send them packages, typically to the next Pokémon Center they're traveling to. Inside a typical Pokémon Center, one can find a front desk, a lobby (sometimes with vending machines), a Poké Ball room, an Emergency Room with plenty of beds for injured Pokémon, a recovery room, a waiting room, rooms for lodging, and a cafeteria. A lobby may also have a large widescreen TV or several smaller TVs so Trainers can watch typically Pokémon-oriented shows, such as Sinnoh Now, Pokémon Contest broadcasts, and major competitions like the Pokémon Leagues of each region and the Grand Festival. A typical sleeping room has a desk and chair and two sets of bunk beds to maximize space, and girls do not have to sleep in separate rooms from boys. At least one Pokémon Center was shown in Uncrushing Defeat! to have a small library with a PC (presumably connected to some network akin to the Internet), as an information room. It is unknown how these activities performed by a Pokémon Center are financed. On the outside, they come in all shapes and sizes, but usually have a rather large P somewhere.